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| Product Name | SMAD2, Recombinant, Human, aa1-467, His-Tag (Mothers Against Decapentaplegic Homolog 2) |
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| Description | Purity ~95% (SDS-PAGE). SMAD2 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated SMAD2 is then able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. TGF-beta 1 acts on adjacent stromal cells to turn on SMAD2 signalling that could lead to stromal decidualization. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells. Source: Recombinant protein corresponding to human SMAD2, a single, non-glycosylated polyp |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 299529 |
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| Order / More Info | SMAD2, Recombinant, Human, aa1-467, His-Tag (Mothers Against Decapentaplegic Homolog 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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