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| Product Name | SMAD2, Recombinant, Human, aa2-467, His-Tag (Mothers Against Decapentaplegic Homolog 2) |
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| Description | Purity ~90% (SDS-PAGE). Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Source: Recombinant protein corresponding to aa2-467 from human SMAD2, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~56.2kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | JV18-1Mad-related protein 2, hMAD-2 SMAD family member 2, SMAD 2, Smad2, hSMAD2 |
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| Gene, Accession, CAS # | SwissProt: Q15796 |
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| Catalog # | 375329 |
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| Order / More Info | SMAD2, Recombinant, Human, aa2-467, His-Tag (Mothers Against Decapentaplegic Homolog 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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