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| Product Name | SMAD3, Recombinant, Human, aa1-425, His-SUMO-Tag (Mothers Against Decapentaplegic Homolog 3) |
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| Description | Purity ~90% (SDS-PAGE). Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Source: Recombinant protein corresponding to aa1-425 from human SM |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3 |
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| Gene, Accession, CAS # | SwissProt: P84022 |
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| Catalog # | 375330 |
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| Order / More Info | SMAD3, Recombinant, Human, aa1-425, His-SUMO-Tag (Mothers Against Decapentaplegic Homolog 3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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