| 产品详情 |
| Edit |   |
|---|
| Product Name | SOCS3, Recombinant, Rat, aa1-225, His-Tag (Suppressor of Cytokine Signaling 3) |
|---|
| Description | Purity ~90% (SDS-PAGE). SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST. Source: Recombinant protein corresponding to aa1-225 from rat SOCS3, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~26.8kD AA |
|---|
| Size | 10ug, 50ug, 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Cytokine-inducible SH2 protein 3 |
|---|
| Gene, Accession, CAS # | SwissProt: O88583 |
|---|
| Catalog # | 375368 |
|---|
| Price | |
|---|
| Order / More Info | SOCS3, Recombinant, Rat, aa1-225, His-Tag (Suppressor of Cytokine Signaling 3) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|