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| Product Name | PTPRs, Recombinant, Human (Protein Tyrosine Phosphatase Receptor-type Sigma, PTPRS) |
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| Description | Purity ~95% (SDS-PAGE). Phosphatase Receptor-type sigma (PTPRs), also known as PTPs, is a 200kD type I transmembrane glycoprotein that is a member of the class 2A (LAR) subfamily of the protein tyrosine phosphatase (PTP) family (1). Human PTPRs cDNA encodes 1948aa including a 29aa signal sequence, a 1253aa extracellular domain (ECD) with three C2-type Ig domains and eight Fibronectin (Fn) type III domains, a transmembrane domain, and a cytoplasmic region with two PTP domains (1, 2). Multiple differentially expressed splice variants lack sections of the Ig and/or Fn domains and/or cytoplasmic juxtamembrane sequence (1, 2). PKC activation in the cell promotes endoprotease cleavage of PTPRs, releasing the 140-160kD ECD (3). The human PTPRs ECD shares 93%aa sequence identity with the nearest isoform of mouse and rat PTPRs, 96% with bovine PTPRs, and 97% with porcine PTPRs. Activity of PTPRs can be inhibited by bisphosphonates (2). PTPRs is a receptor for several proteins, including neural |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 5802, Accession: NP_570924 |
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| Catalog # | 167692 |
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| Order / More Info | PTPRs, Recombinant, Human (Protein Tyrosine Phosphatase Receptor-type Sigma, PTPRS) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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