| 产品名称 |
c-KIT, Recombinant, Human, GST-Tag (PBT, Stem Cell Factor, SCF Receptor, SCFR, CD117) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | c-KIT, Recombinant, Human, GST-Tag (PBT, Stem Cell Factor, SCF Receptor, SCFR, CD117) |
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| Description | Purified (~70-90%). c-KIT is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. c-KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in c-KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed curbing neoplastic mast cell growth. Source: Recombinant protein corresponding to human c-KIT, fused to GST-Tag at N-terminal, expressed in Insect cells. Molecular Weight: ~73kD Specific Activity: 16nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_000222, SwissProt: P10721 |
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| Catalog # | 499832 |
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| Order / More Info | c-KIT, Recombinant, Human, GST-Tag (PBT, Stem Cell Factor, SCF Receptor, SCFR, CD117) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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