| 产品详情 |
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| Product Name | PHIP |
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| Description | Highly Purified (~90%). PHIP is a bromodomain-containing protein that binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival. It stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Source: Recombinant protein corresponding to bromodomain 1, aa1146-1287, from human PHIP, fused to His-tag at N-terminal, expressed in E. coli. Molecular Weight: ~17kD AA Sequence: MHHHHHHSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDLQAYPMY CTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDL LLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEE Applications: Suitable for use in the study of bromodomain binding assays, screening inhibitors, and selectivity profiling. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PHIP (BD1), Recombinant, Human, aa1146-1287, His-Tag (Bromodomain Pleckstrin Homology Domain Interacting Protein, IRS-1 PH Domain-Binding Protein, WDR11, BRWD2) |
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| Gene, Accession, CAS # | Accession: NM_017934, SwissProt: Q8WWQ0 |
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| Catalog # | 298447 |
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| Order / More Info | PHIP from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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