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| Product Name | Noggin, Recombinant, Mouse, aa28-232 (Nog) |
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| Description | Purity ~95% (SDS-PAGE). Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Human Noggin cDNA encodes a 232aa precursor protein; cleavage of a 19aa signal peptide generates the 213aa mature protein which contains an N-terminal acidic region, a central basic heparin-binding segment and a C-terminal cysteine-knot structure. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin is very highly conserved among vertebrates, such that mature mouse Noggin shares 99%, 100%, 98%, 97% and 87% aa sequence identity with human, rat, bovine, equine and chicken Noggin, respectively. Noggin binds some BMPs such as BMP-4 with high affinity and others such as BMP-7 with lower affinity. It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors. During embryogenesis, Noggin antagonizes specific BMPs at defined times, |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P97466 |
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| Catalog # | N3100-15C |
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| Order / More Info | Noggin, Recombinant, Mouse, aa28-232 (Nog) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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