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| Product Name | Persephin, Recombinant, Human (PSP, Neurotrophic Factor) |
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| Description | Purity ≥95%, as determined by SDS-PAGE and visualized by silver stain.Endotoxin: ≤ 1.0 EU/1 ug. Persephin is a secreted protein belonging to the glial cell line-derived neurotrophic factor (GDNF) family of the TGF-b superfamily. It shares 38-46% amino acid (aa) identity with family members GDNF, neurturin and artemin. Persephin is expressed at very low levels in most tissues.1 The 156 aa, 10-12kD mature protein contains a signal sequence, a pro-domain and a 96 aa mature sequence with several cysteines that are conserved among family members. It circulates as an unglycosylated disulfide-linked homodimer. Mature human persephin shares 81% and 80%, 89% and 87% amino acid sequence identity with mouse, rat, cow and dog persephin, respectively. Like other GDNF family members, persephin acts through engagement of GRFa4, a glycosylphosphatidylinositol (GPI)-linked GDNF receptor family (GRF) member that signals through the receptor tyrosine kinase RET. Persephin is reported to promote both the |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: O60542 |
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| Catalog # | P3355-02C |
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| Order / More Info | Persephin, Recombinant, Human (PSP, Neurotrophic Factor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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