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| Product Name | Persephin, Recombinant, Mouse (PSP, Pspn) |
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| Description | Purity ≥98% by SDS-PAGE gel and HPLC analyses. Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFRa (a1-a4) receptors. The GFRa4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons. Recombinant murine Persephin is a disulfide-linked homodimer, composed of two 10.3kD polypeptide chains (96 total aa residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-cha |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143468 |
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| Order / More Info | Persephin, Recombinant, Mouse (PSP, Pspn) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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