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| Product Name | Pertussis Toxin, Mutant |
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| Description | Five distinct bands when run on 12% SOS-polyacrylamide gels. The Pertussis Toxin Mutant contains a modified sequence encoding the enzyme subunit. Virulence of this pertussis mutant is greatly reduced relative to that found with the wild type. The pertussis mutant protein is isolated from the TY-178 strain of Bordetella bronchiseptica which contains a genetically modified sequence encoding the S1 sub unit. Site-directed mutagenesis was used to replace amino acid residues arginine-9 with lysine (R9K) and glutamic acid-129 with alanine (E129A). Genetically inactivated toxin has reduced activity relative to the native toxin and may be used as an antigen or as a carrier to promote an immune response. Source: Pertussis Toxin, Mutant, strain TY-178 from Bordetella bronchiseptica Biological Activity: The lowest concentration of toxin at which a positive response (clustered growth pattern) was obtained was 3.3ng/ml. The adenylate cyclase activity of this lot, in the presence of 1umolar calmodul |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 215961 |
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| Order / More Info | Pertussis Toxin, Mutant from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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