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| Product Name | IRE1 Inhibitor III, 4u8C |
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| Description | Purity ~95% (HPLC). A cell-permeable coumarin o-hydroxyaldehyde that inhibits IRE1 RNase activity in a time- and dose-dependent manner (IC50=550 and 45nM, respectively, with 0 and 16min drug preincubation in RNA cleavage assays) by covalently targeting IRE1 Lys907 via Schiff base formation, effectively preventing ER stress-induced site-specific mRNA splicing as well as RIDD (Regulated IRE1-Dependent Degradation) mRNA degradation (IC50=6.9 and 4.1uM, respectively, against Xbp1 splicing and Scara3 degradation) in MEF cultures following Tunicamycin treatment. Comparing to STF083010, 4u8C is also shown to inhibit IRE1 autophosphorylation in cell-free assays via Schiff base formation with IRE1 Lys599 in the absence of ADP, however cellular nucleotide prevents 4u8C from targeting IRE1 Lys599 intracellularly. Formula: C11H8O4 Molecular Weight: 204.2 Solubility: DMSO (25mg/ml) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IRE1 Inhibitor III, 4u8C (8-Formyl-7-hydroxy-4-methylcoumarin, 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde, ER-to-Nucleus Signaling 1 Inhibitor III, Inositol-Reguiring Protein 1 Inhibitor III) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217466 |
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| Order / More Info | IRE1 Inhibitor III, 4u8C from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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