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| Product Name | PCNA, Recombinant, Human, aa1-261, His-Tag (Proliferating Cell Nuclear Antigen) |
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| Description | Purity ~90% (SDS-PAGE). Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. Source: Reco |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cyclin |
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| Gene, Accession, CAS # | SwissProt: P12004 |
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| Catalog # | 374632 |
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| Order / More Info | PCNA, Recombinant, Human, aa1-261, His-Tag (Proliferating Cell Nuclear Antigen) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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