| 产品详情 |
| Edit |   |
|---|
| Product Name | p53 Upregulated Modulator of Apoptosis/Bcl 2 Binding Component 3, CT, Blocking Peptide (PUMA/bbc3) |
|---|
| Description | Purified 60-70%. Blocking Peptide for anti-p53 Upregulated Modulator of Apoptosis/Bcl 2 Binding Component 3 (PUMA/bbc3) (CT), Catalog #: P1001-32W Synthetic peptide (PLPRGHRAPEMEPN) corresponding to amino acids 180 to 193 of human PUMA-a (1). Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identi?ed recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Applica |
|---|
| Size | 50ug |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA WB |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | P1001-32P2 |
|---|
| Price | |
|---|
| Order / More Info | p53 Upregulated Modulator of Apoptosis/Bcl 2 Binding Component 3, CT, Blocking Peptide (PUMA/bbc3) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|