| 产品详情 |
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| Product Name | IRAK 4, Control Peptide (IL-1R-associated Kinase) |
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| Description | Control Peptide for I8600-17. Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-kB and MAP kinase (MAPK) by IL-1R/TLR (1-3). A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4 (4,5). Overexpression of IRAK-4 activates NF-kB and MAPK pathways. IRAK- 4 interacts with and phosphorylates IRAK-1. IRAK-4- deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK- 4 are impaired in their responses to viral and bacterial challenges (5,6). Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity. Applications: Suitable for use in ELISA, Western Blot, Antibody Blocking. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | I8600-17P |
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| Order / More Info | IRAK 4, Control Peptide (IL-1R-associated Kinase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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