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| Product Name | Rcan2, Recombinant, Mouse, aa2-197, His-Tag |
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| Description | Purity ~95%. Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Source: Recombinant protein corresponding to mouse RCAN2 Isoform 2, fused to His-tag at C-terminal expressed in E.coli. Molecular Weight: ~26kD Ap |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Rcan2, Recombinant, Mouse, aa2-197, His-Tag (Calcipressin-2, Calcineurin Inhibitory Protein ZAKI-4, Down Syndrome Candidate Region 1-like Protein 1, Myocyte-enriched Calcineurin-interacting Protein 2, MCIP2, Regulator of Calcineurin 2, Dscr1l1, Zaki4) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149777 |
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| Order / More Info | Rcan2, Recombinant, Mouse, aa2-197, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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