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| Product Name | Caspase 8 (FLICE, MASH, Mch5), Active, Recombinant, His-tagged, Human |
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| Description | Purity ≥95% by SDS-PAGE. Caspase-8 (also known as FLICE/MASH/Mch5) is a member of the interleukin-1b converting enzyme (ICE) family of cysteine proteases. Like other caspases, caspase-8 also exists in cells as an inactive proenzyme. During apoptosis pro-caspase-8 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed form of caspase-8 consists of large and small subunits which associate to form the active enzyme. The active recombinant human caspase-8 is routinely tested for its ability to enzymatically cleave the caspase-8 colorimetric substrate Ac-IETD-pNA. The E. coli expressed human caspase-8 spontaneously undergoes autoprocessing to form active caspase-8. The active caspase-8 efficiently cleaves substrates consisting of consensus sequence IETD (e.g., IETD-AFC and IETD-pNA). Applications: Suitable for use in Screening for caspase inhibitors, Studying enzyme regulation, Determining target substrates, and as Positive control in caspas |
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| Size | 25u, 100u |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2087-60 |
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| Order / More Info | Caspase 8 (FLICE, MASH, Mch5), Active, Recombinant, His-tagged, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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