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| Product Name | Phosphoinositide 3-Kinase delta, p110 delta, p85 alpha, Recombinant, Human (PI3K) |
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| Description | Purity ≥ 95% by SDS-PAGE. The class IA PI3K is expressed in endothelial and in white blood cells. Recently it was shown that the inactivation of PI3K in bone marrow mast cells (BBMCs) leads to defective stem cell factor-mediated proliferation, adhesion and migration of these cells, and to impaired allergen-IgEinduced degranulation and cytokine release. In neutrophils a role for PI3K in TNF -induced signalling was demonstrated by a reduction in Akt phosphorylation and PDK1 activity upon treatment with the specific inhibitor IC87114. The PI3K catalytic and regulatory subunits are coexpressed in Sf9 insect cells. The catalytic subunit carries a GST-Tag and the heterodimer was purified by affinity chromatography. The GST-Tag facilitates the protein's application in typical GST pull-down assays. Phosphoinositide 3-kinases (PI3Ks) phosphorylate phosphatidylinositols (PIs) at their 3?-OH position generating lipid second messengers and thereby regulate numerous biological processes including c |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: O00329 |
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| Catalog # | P4073-34E |
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| Order / More Info | Phosphoinositide 3-Kinase delta, p110 delta, p85 alpha, Recombinant, Human (PI3K) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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