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| Product Name | MOB1A, Recombinant, Human, aa2-216, His-SUMO-Tag (MOB Kinase Activator 1A) |
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| Description | Purity ~90% (SDS-PAGE). Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Source: Recombinant protein corresponding to aa2-216 from human MOB1A, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~40.9kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mob1 alpha, Mob1A, Mob1 homolog 1 BMps one binder kinase activator-like 1B |
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| Gene, Accession, CAS # | SwissProt: Q9H8S9 |
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| Catalog # | 374247 |
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| Order / More Info | MOB1A, Recombinant, Human, aa2-216, His-SUMO-Tag (MOB Kinase Activator 1A) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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