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| Product Name | Phosphoinositide 3 kinase, p85 alpha, p110 beta, active, Recombinant, Human (PI3K) |
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| Description | Purified using Ni2+/NTA-agarose. ~87% by SDS-PAGE and Coomassie blue staining. The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin receptor substrate (IRS) proteins (e.g. IRS-1 and IRS-2). It was also shown that PI3Kb is involved in apoptosis in human colon carcinoma cells. Injection of neutralizing antibodies specific to p110b in WiDr, HCT116 and CO 115 adenocarcinoma cells inhibited de novo DNA synthesis. PI3Kb is the major PI3K isoform required for apoptotic cell and Fc-g receptor mediated phagocytosis shown for primary mouse macrophages and the Jurkat human leukemia T cell line. It was shown by several research groups that the catalytic subunit of PI3Kb can be activated by Gbg subunits of G-protein coupled receptors. Recombinant Human Phosphoinositide 3-kinase beta is a glycosilated p |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: U79143 |
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| Catalog # | P4073-30 |
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| Order / More Info | Phosphoinositide 3 kinase, p85 alpha, p110 beta, active, Recombinant, Human (PI3K) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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