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| Product Name | 2-Cl-IB-MECA |
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| Description | High affinity and extremely selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. Exhibits high selectivity over the Na+-independent adenosine transporter. Adenosine A(3) receptor (A3AR) is coupled to G proteins that are involved in a variety of intracellular signaling pathways and physiological functions. 2-Chloro-N(6)-(3-iodobenzyl) adenosine-5'-N-methylcarboxamide (Cl-IB-MECA), an agonist of A3AR, has been reported to induce cell death in various cancer cells. However, the effect of CI-IB-MECA on glioma cell growth is not clear. This study was undertaken to examine the effect of CI-IB-MECA on glioma cell viability and to determine its molecular mechanism. CI-IB-MECA inhibited cell proliferation and induced cell death in a dose- and time-dependent manner. Treatment of CI-IB-MECA resulted in an increase in intracellular Ca(2+) followed by enhanced reactive oxygen species (ROS) generation. EGTA and N-ace |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide; 2-Chloro-N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide; 2-Cl IB-MECA; CF 102; Chloro-IB-MECA; |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 159522 |
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| Price | |
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| Order / More Info | 2-Cl-IB-MECA from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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