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| Product Name | Aurora Kinase Inhibitor VI, ZM447439 |
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| Description | Purity ~98% (HPLC). A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50=110 and 130nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50=0.88, 1.03 and 1.79uM for Lck, Src and MEK1, respectively, and IC50>10uM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20uM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells. Formula: C29H31N5O4 Molecular Weight: 513.6 Solubility: DMSO (50mg/ml) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Aurora Kinase Inhibitor VI, ZM447439 (4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217204 |
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| Order / More Info | Aurora Kinase Inhibitor VI, ZM447439 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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