| 产品详情 |
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| Product Name | Ischemin |
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| Description | Purity ~99% (HPLC). A cell-permeable azobenzene compound that reversibly targets CREB-binding protein bromodomain (CBP-BRD) acetyl-lysine binding pocket (=19uM) with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B ( = 37, 41, 70 and >100uM, respectively) and disrupts CBP interaction with the binding partners. Blocks CBP-p53 interaction and alters the post-translational modification states on p53 and histones. Shown to inhibit the transcription functions of p53 on DNA damage (IC50=5uM for p53-induced p21 activation in Luc-U2OS cells) and suppress cardiac myocyte apoptosis during ischemia conditions. Formula: C15H17N3SO4 Molecular Weight: 335.4 Solubility: DMSO (50mg/ml, orange solution) |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Ischemin (MS120, (E)-5-(2-Amino-4-hydroxy-5-methyl-phenylazo)-2,4-dimethyl-benzenesulfonic Acid, BRD4 Inhibitor II) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217469 |
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| Order / More Info | Ischemin from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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