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| Product Name | VHL Complex, Active, Recombinant, Human (VCB-Cul2 complex, ECV complex, CBCVHL) |
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| Description | Purity ~86% (SDS-PAGE, Coomassie blue staining). The VHL complex is a multi-subunit ubiquitin ligase composed of VHL, Elongin B, Elongin C, Cul2 and Rbx1. The VHL protein serves as the substrate recognition component and is linked by Elongin C to a heterodimeric Cul2/Rbx1 module that functions as a potent activator of the ubiquitination of target proteins by an E2 conjugating enzyme. Elongin B interacts with the complex through Elongin C and appears to stabilize the binding of Elongin C to VHL. The primary function of the VHL complex is to regulate HIF (hypoxia inducible factor) activity by targeting the hydroxylated HIF-1a subunit for ubiquitination and rapid proteasomal degradation under normoxic conditions. It therefore plays an important role in the regulation of hypoxia-inducible genes such as the vascular endothelial growth factor (VEGF) and glucose transport-1 (Glut-1). Mutations in VHL are associated with the inherited von Hippel-Lindau (VHL) cancer syndrome and numerous forms |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_000551, NM_005648, NM_007108, NM_003591, NM_014248 |
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| Catalog # | 29641 |
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| Order / More Info | VHL Complex, Active, Recombinant, Human (VCB-Cul2 complex, ECV complex, CBCVHL) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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