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| Product Name | Sepiapterin Reductase, 1-261 aa, Recombinant, Human |
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| Description | Purity ≥95% by SDS-PAGE. Sepiapterin reductase (SPR) belongs to the short-chain dehydrogenase/reductase (SDR) family and also reduces various exogenous carbonyl compounds including phenylpropanedione. SPR is an essential enzyme for the biosynthesis of tetrahydrobiopterin, an essential cofactor for aromatic amino acid hydrolases including tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. Defects in SPR cause DOPA-responsive dystonia defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Recombinant human SPR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MEGGLGRAVC LLTGASRGFG RTLAPLLASL LSPGSVLVLS ARNDEALRQL EAELGAERSG LRVVRVPADL GAEAGLQQLL GALRELPRPK GLQRLLLINN AGSLGDVSKG FVDLSDSTQV NNYWALNLTS MLCLTSSVLK AFPDSPGLNR TVVNISSLCA LQPFKGWALY CAGKAARDML FQVLALEEPN VRVLNYAPGP LDTDMQQLAR ETSVDPDMRK GLQELKAKGK LVD |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Sepiapterin Reductase, 1-261 aa, Recombinant, Human (SPR, sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) |
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| Gene, Accession, CAS # | Accession: NP_003115 |
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| Catalog # | S9151 |
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| Order / More Info | Sepiapterin Reductase, 1-261 aa, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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