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| Product Name | Semaphorin 4A, Fc Chimera, Recombinant, Human (Sema4A) |
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| Description | Purity ≥85%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤1EU/ug. Semaphorin 4A (Sema4A, previously semB) is a Class 4 transmembrane Semaphorin with activity in the immune and nervous systems. The 761aa human Sema4A precursor contains a 32aa signal sequence, a 651aa extracellular domain (ECD) containing sema, PSI and C2-type immunoglobulin domains, a 21aa transmembrane domain, and a 57aa cytoplasmic domain with two Ser/Thr phosphorylation sites. Human Sema4A ECD shares 87%, 87%, 86% and 85% aa identity with mouse, rat, bovine and canine Sema4A, respectively, and shares 32-37% aa identity with other human Sema4 family members. Of six reported splice variants with 723, 629, 370, 321, 236 and 220 aa, five lack the N-terminus and/or portions of the sema domain, and three lack the transmembrane and cytoplasmic domains in the C-terminus. Sema4A was first described as a molecule that enhances T cell activation and interacts with TIM-2 (T cell |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 64218, SwissProt: Q9H3S1 |
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| Catalog # | S0668-54 |
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| Order / More Info | Semaphorin 4A, Fc Chimera, Recombinant, Human (Sema4A) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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