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| Product Name | Semaphorin 3A, Fc Chimera, Recombinant, Mouse (Semaphorin III, Sema III, SEMA3A, SEMAD) |
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| Description | Purity ≥90% by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin: ≤1EU/ug (LAL). Semaphorin 3A (Sema3A; previously sem D, sema III or collapsin) is one of six Class 3 secreted semaphorins which share ~40-50% aa identity. Class 3 semaphorins are potent chemorepellents that function in axon and/or vascular guidance during development. The 772aa mouse Sema3C contains a 20aa signal sequence, an ~500aa N-terminal Sema domain that forms a b-propeller structure similar to that found in integrin molecules, a PSI domain, a furin-type cleavage site, an Ig-like domain, and a C-terminal basic domain. Covalent dimerization plus cleavage at the C-terminus are required for activity of class 3 semaphorins. The 95kD mature mouse Sema3A shares at least 95% aa identity with human, rat, equine and canine Sema3A, and 90% and 86% aa identity with chick and zebrafish Sema3A, respectively. Type 3 semaphorins transduce signals through transmembrane plexins, either directly or by bind |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: O08665 |
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| Catalog # | S0668-47R |
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| Order / More Info | Semaphorin 3A, Fc Chimera, Recombinant, Mouse (Semaphorin III, Sema III, SEMA3A, SEMAD) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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