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| Product Name | FGFR4, Recombinant, Human, GST-Tag (TKF, JTK2, CD334, MGC20292) |
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| Description | Purified (~70-90%). FGFR4 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. FGFR4 preferentially binds acidic fibroblast growth factor and is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4 gene expression is up-regulated in doxorubicin-treated, apoptosis-resistant cancer cell clones. Ectopic expression of FGFR4 in cancer cells leads to reduced apoptosis sensitivity on treatment with doxorubicin or cyclophosphamide, whereas knockdown of endogenous FGFR4 expression in breast cancer cell lines has the opposite effect. Source: Recombinant protein corresponding to human FGFR4, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~65kD Specific Activity: 76nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_002011 |
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| Catalog # | 500012 |
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| Order / More Info | FGFR4, Recombinant, Human, GST-Tag (TKF, JTK2, CD334, MGC20292) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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