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| Product Name | Caspase 9, aa41-56, I16, Blocking Peptide (ICE-LAP6, Mch6, Apaf 3) |
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| Description | Purified 60-70%. Peptide corresponding to amino acids 41 to 56 of human caspase-9 (1-3). Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3 (1-3). Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation (3). Caspase-9 is also activated by granzyme B and CPP32 (1,2). Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFa, TRAIL, anti-CD-95, FADD, and TRADD (4). Caspase-9 is expressed in a variety of human tissues (1,2). |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2088-30P |
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| Order / More Info | Caspase 9, aa41-56, I16, Blocking Peptide (ICE-LAP6, Mch6, Apaf 3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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