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| Product Name | Caspase 3, active, Recombinant, Human (CPP-32, Apoptain, Yama, SCA-1) |
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| Description | Caspase-3 (also know as CPP32, Yama and apopain) is a member of the interleukin-1b converting enzyme (ICE) family of cysteine proteases. Caspase-3 exists in cells as an inactive 32kD proenzyme. During apoptosis procaspase-3 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases, such as caspase-6 (Mch2), caspase-8 (Flice) and grazyme B. The processed form of caspase-3 consists of large (17 kD) and small (11 kD) subunits which associate to form the active enzyme. The active caspase-3 has been shown involving in the proteolysis of several important molecules, such as poly (ADP-ribose) polymerase (PARP), the sterol regulatory element binding proteins (SREBPs), focal adhesion kinase (FAK), and others. The active recombinant caspase-3 is routinely tested for its ability to enzymatically cleave the caspase-3 colorimetric substrate Ac-DEVD-pNA. The recombinant active human caspase-3 expressed in E. coli and fused with His tag, spontaneously undergoes auto |
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| Size | 25u, 100u |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2087-13 |
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| Order / More Info | Caspase 3, active, Recombinant, Human (CPP-32, Apoptain, Yama, SCA-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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