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| Product Name | Caspase 4, Active, Recombinant, Human (ICErelII, TX, Ich-2) |
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| Description | Caspase-4 (also know as ICErelII, TX, Ich-2) is the member of the caspase family of cysteine proteases. Caspase-4 exists in cells as an inactive pro-enzyme. The pro-enzyme is matured by proteolysis to yield large and small subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. To date the mechanism of caspase-4 activation and roles of caspase-4 in apoptosis are poorly understood. Active recombinant human caspase-4 was expressed in E. coli. The expressed caspase-4 spontaneously undergoes auto-processing to yield subunits caracteristic of the native enzyme. The active caspase-4 is routinely tested at Untied States Biological for its ability to enzymatically cleaves the substrate WEHD-AFC or WEHD-pNA. Applications: Useful in screening caspase inhibitors, studying enzyme regulation and kinetics, determining target substrate or as a positive control in caspase activity assays. We recommend using 1 unit per assay for analyzing caspase activity. |
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| Size | 25U, 100U |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2087-24B |
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| Order / More Info | Caspase 4, Active, Recombinant, Human (ICErelII, TX, Ich-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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