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| Product Name | Caspase 5, Active, Recombinant, Human (Ich-3, ICErel-III, TY) |
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| Description | Purity ~95% by SDS-PAGE. Caspase-5 (also know as ICErel III, TY) is the member of the caspase family of cysteine proteases. Caspase-5 exists in cells as an inactive pro-enzyme. The pro-enzyme is matured by proteolysis to yield large and small subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. To date the mechanism of caspase-5 activation and roles of caspase-5 in apoptosis are poorly understood. United States Biological's active recombinant human caspase-5 was expressed in E. coli. The expressed caspase-5 spontaneously undergoes auto-processing to yield subunits characteristic of the native enzyme. The active caspase-5 is routinely tested for its ability to enzymatically cleaves the caspase-5 substrates WEHD-AFC or WEHD-pNA. In combination with caspase-5 activity assays, the enzyme is useful in screening caspase inhibitors, studying enzyme regulation and kinetics, determining target substrate or as a positive control in caspase-5 activity as |
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| Size | 25U, 100U |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2087-24E |
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| Order / More Info | Caspase 5, Active, Recombinant, Human (Ich-3, ICErel-III, TY) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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