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| Product Name | Caspase 7, active, Recombinant, Human (Mch-3, ICE-LAP3, CMH-1) |
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| Description | Purity ≥ 90% by SDS-PAGE. Caspase-7 (also know as Mch3, ICE-LAP3, CMH-1) is a member of the interleukin-1b converting enzyme (ICE) family of cysteine proteases. Same as other caspases, caspase-7 also exists in cells as an inactive proenzyme. During apoptosis procaspase-7 is processed at aspartate residues by self-proteolysis and/or cleavage by another caspase. The processed form of caspase-7 consists of large and small subunits which associate to form the active enzyme. The active caspase-7 has been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP), an enzyme that is involved in DNA repair and genomic maintenance. The upstream sequence of the PARP cleavage site, DEVD, has been utilized as a basis for synthesis of caspase-3 and -7 substrates DEVD-AFC and DEVD-pNA. The active recombinant caspase-7 is routinely tested for its ability to enzymatically cleave the caspase-7 colorimetric substrate Ac-DEVD-pNA. The active recombinant human caspase-7 was expressed in E. |
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| Size | 25U, 100U |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2087-29A |
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| Order / More Info | Caspase 7, active, Recombinant, Human (Mch-3, ICE-LAP3, CMH-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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