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| Product Name | Y-27632 Dihydrochloride (ROCK Inhibitor) |
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| Description | Purity ≥98% (HPLC). Contains approx.1.4% water. Y-27632 (also called Y27632 or Y 27632) is a potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor. Ki values are 0.14, 26, 25 and >250uM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase, respectively. Prevents apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem cells (hES) without affecting their pluripotency. Tumor cell invasion and metastasis suppressor. Smooth muscle relaxant. Decreases liver fibrosis by hepatic stellate cell growth inhibition. Antinociceptive. Blocks generation of inflammatory cytokines. Stem cell research modulator. Increases survival rate of hES cells undergoing cryopreservation. Synonyms: (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride; trans-4-[(R)-1-[(tert-Butyloxycarbonyl)amino]ethyl]-N-(4-pyridyl)cyclohexanecar |
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| Size | 1mg, 5mg, 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride; trans-4-[(R)-1-[(tert-Butyloxycarbonyl)amino]ethyl]-N-(4-pyridyl)cyclohexanecarboxamide-d4; [(1R)-1-[trans-4-[(4-Pyridinyl-d4-amino)carbonyl]cyclohexyl]ethyl]-carbamic Acid 1,1-Dimethyethyl Ester |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | Y0110 |
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| Order / More Info | Y-27632 Dihydrochloride (ROCK Inhibitor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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