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| Product Name | Leptin, Recombinant, Human (Ob, Obese Protein, Obesity Factor) |
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| Description | Purity ≥95% by SDS PAGE. Human leptin is a 16kD nonglycosylated hormone that is produced in mature adipocytes. Leptin acts primarily in the hypothalamus to reduce food intake and body weight. In ob/ob mice, the gene encoding leptin is mutated, resulting in morbid obesity and associated abnormalities, including hyperphagia, hypothermia, diabetes and infertility. The function of leptin in regulating appetite and metabolism, as well as the possibility of using leptin as a therapeutic agent, are currently under intense investigation. Recombinant human leptin was overexpressed as insoluble protein aggregate in E. coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Molecular Weight: 16kD (147amino acids) Sequence: MVPIQKVQDD/ TKTLIKTIVT/ RINDISHTQS/ VSSKQKVTGL/ DFIPGLHPIL/ TLSKMDQTLA/ VYQQILTSMP/ SRNVIQISND/ LENLRDLLHV/ LAFSKSCHLP/ WASGLETLDS/ LGGVLEASGY/ STEVVALSRL/ QGSLQDMLWQ/ LDLSPGC |
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| Size | 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | L1670-15J |
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| Order / More Info | Leptin, Recombinant, Human (Ob, Obese Protein, Obesity Factor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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