| 产品详情 |
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| Product Name | Leptin, Recombinant, Rat (Lep, Obesity Factor, Obese, Ob) |
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| Description | Purity ~98% (SDS-PAGE and HPLC). Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Rat Leptin is a 16.2kD protein containing 147aa. Source: Recombinant protein corresponding to rat Leptin, expressed in E.coli. Biological Activity: Determined by an in vivo assay using the ob/ob mouse obesity model and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5ug leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: MVPIHKVQDD TKTLIKTIVT RINDISHTQS VSARQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQILTSLP SQNVLQIAHD LENLRDLLHL LAFS |
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| Size | 200ug, 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149717 |
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| Order / More Info | Leptin, Recombinant, Rat (Lep, Obesity Factor, Obese, Ob) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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