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| Product Name | Caspase-1, Recombinant, Mouse |
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| Description | Caspase-1 (also know as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45kD proenzyme. The pro-enzyme is matured by proteolysis to yield large (20kD) and small (10kD) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form. The recombinant active mouse caspase-1 was expressed in E. coli. The active caspase-1 preferentially cleaves caspase-1 substrates (e.g., YVAD-AFC or YVAD-pNA) and is routinely tested for its ability to enzymatically cleave these two substrates Ac-YVAD-pNA or Ac-YVAD-AFC. Source: Recombinant protein corresponding to mouse Caspase-1, expressed in E. coli. Molecular Weight: ~20kD (large) ~10kD (small) Biological Activity: ~3500units/mg |
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| Size | 25U, 100U |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Caspase-1, Recombinant, Mouse (Casp1, Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE, IL-1 beta-converting Enzyme, p45, Il1bc) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 169636 |
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| Order / More Info | Caspase-1, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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