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| Product Name | Caspase-1, Recombinant, Rat, Active |
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| Description | Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45kD proenzyme. The pro-enzyme is matured by proteolysis to yield large (20kD) and small (10kD) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form. The recombinant rat caspase-1 was expressed in E. coli as a single polypeptide of 284aa with molecular weight of 34.6. The caspase-1 is purified and activated by proprietary techniques. Source: Recombinant protein corresponding to rat Caspase-1, expressed in E. coli. Molecular Weight: ~34.6kD Biological Activity: The caspase-1 is routinely tested for its ability to cleave these two substrates Ac-YVAD-pNA or Ac-YVAD-AFC (1103-200). |
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| Size | 25units |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Caspase-1, Recombinant, Rat, Active (Interleukin-1 Beta Convertase, Interleukin-1 Beta-converting Enzyme, IL-1BC, P45) |
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| Gene, Accession, CAS # | Casp1, SwissProt: P43527 |
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| Catalog # | 301188 |
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| Order / More Info | Caspase-1, Recombinant, Rat, Active from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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