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| Product Name | SPAM1, Recombinant, Bovine, His-Tag (Sperm Adhesion Molecule 1) |
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| Description | Purity ~95% (SDS-PAGE). Sperm adhesion molecule 1 (SPAM1), also known as PH20 hyaluronidase (1), is encoded by one of the six hyaluronidaselike genes (1, 2, 3). SPAM1 is a GPIanchored enzyme located on the sperm surface and inner acrosomal membrane (4). SPAM1 degrades hyaluronic acid (HA), a major structural glycosaminoglycan found in extracellular matrices and basement membranes. The enzyme activity enables sperm to penetrate through the HArich cumulus cell layer surrounding the oocyte and therefore facilitates the fertilization process (5). However, detailed enzymatic analysis of this enzyme is hindered by the limited techniques/methods available to monitor the HA degradation products (6). A novel method for analyzing SPAM1 activity was utilized here. Because of the structural similarity between HA (repeating units of GlcAβ13GlcNAc) and chondroitin sulfate (repeating units of GlcAβ13GalNAc), the enzyme is also able to hydrolyze chondroitin sulfate. In this assay, radiolabel |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | S5401-40 |
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| Order / More Info | SPAM1, Recombinant, Bovine, His-Tag (Sperm Adhesion Molecule 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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