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| Product Name | Irinotecan, Hydrochloride Salt, Trihydrate |
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| Description | Purity ~99%. Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Solubility: Soluble in DMSO at 100mg/ml; very poorly soluble in ethanol; soluble in water at 25mg/ml; buffers, serum, or other additives may increase or decrease the aqueous solubility. |
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| Size | 100mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Irinotecan, Hydrochloride Salt, Trihydrate ([1,4'-Bipiperidine]-1'-carboxylic Acid (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4',6,7]indolizino[1,2-b]quinolin-9-yl Ester, HCl Trihydrate) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | I8611-02 |
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| Order / More Info | Irinotecan, Hydrochloride Salt, Trihydrate from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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