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| Product Name | NFNB, 1-217aa, E Coli, His tag, E Coli |
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| Description | MW: 26.0 kDa (237aa) confirmed by MALDI-TOF. Purity >95% by SDS-PAGE. NFNB, also known as NFSB, shows the ability to reduce quinines. This protein is an enzyme for activating prodrugs in antibody directed enzyme prodrug therapy. It also capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5- (aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species. Recombinant E Coli NFNB protein, fused to His-tag at N-terminus, was exp |
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| Size | 0.1 mg, 0.5 mg |
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| Concentration | 1 mg/ml (determined by Bradford assay) |
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| Applications | SDS-PAGE |
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| Other Names | [dihydropteridine reductase NAD (P)H-dependent oxygen-insensitive; dprA; nfsB; nfsI; ntr; dihydropteridine reductase; NAD (P)H-dependent; oxygen-insensitive] |
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| Gene, Accession, CAS # | NFNB, Gene ID: 945778, Accession: NP_415110 |
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| Catalog # | MBS203581 |
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| Order / More Info | NFNB, 1-217aa, E Coli, His tag, E Coli from MYBIOSOURCE INC. |
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| Product Specific References | Jarrom D., et al. (2009) Biochemistry. 48 (32):7665-72. ; Singleton DC., et al. (2007) Cancer Gene Ther. 14 (12):953-67.; |
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