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| Product Name | DKK1, Recombinant, Human, aa33-266, His-Tag (Dickkopf-related Protein 1) |
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| Description | Purity ~90% (SDS-PAGE). Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Source: Recombinant protein corresponding to aa33-266 from human DKK1, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~29.7kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SK |
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| Gene, Accession, CAS # | SwissProt: O94907 |
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| Catalog # | 373062 |
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| Order / More Info | DKK1, Recombinant, Human, aa33-266, His-Tag (Dickkopf-related Protein 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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