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| Product Name | DKK1, Recombinant, Human, aa32-266, His-Tag (Dickkopf-related Protein 1, DKK-1, SK) |
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| Description | Purity ~90% (SDS-PAGE). Dickkopf-related protein 1, also known as DKK1, antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Source: Recombinant protein corresponding to human DKK1, fused to His-tag at N-terminal expressed in E.coli. Molecular Weight: ~28.2kD (258aa) AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSTLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CGEGLSCRIQ KDHHQASNSS RLHTCQR |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 137045 |
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| Order / More Info | DKK1, Recombinant, Human, aa32-266, His-Tag (Dickkopf-related Protein 1, DKK-1, SK) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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