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| Product Name | Chloromethylketone-FPR, (FPRCK) (FITC) |
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| Description | Fluorescein labelled FPRCK is prepared by the method of Williams et al. (11). Tri-peptide chloromethylketones have been utilized extensively to irreversibly inhibit various serine proteases. Among the most common chloromethylketones are FPRCK (Phe-Pro-Arg-chloromethylketone), which is a rapid inhibitor of a-thrombin and EGRCK (Glu-Gly-Arg-chloromethylketone), which rapidly inhibits factor Xa. Recently, the modification of these tri-peptide chloromethylketones with reporting groups, such as fluorescent probes, radioactive labels or thioreactive-labels, has provided a unique approach to the study of various serine proteases. These probes are useful because they allow a means of reporting molecular changes in an enzyme, and not its zymogen, while also inhibiting the enzymatic activity. Applications: The fluorescein labelled compounds are useful in both Western Blot and fluorescent imaging applications. |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | IF WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C5028 |
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| Order / More Info | Chloromethylketone-FPR, (FPRCK) (FITC) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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