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| Product Name | Chloromethylketone-EGR, (EGRCK) FITC |
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| Description | Fluorescein labelled EGRCK is prepared by the method of Williams et al. (11). Tri-peptide chloromethylketones have been utilized extensively to irreversibly inhibit various serine proteases (1-5). Among the most common chloromethylketones are FPRCK (Phe-Pro-Arg-chloromethylketone), which is a rapid inhibitor of a-thrombin and EGRCK (Glu-Gly-Arg-chloromethylketone), which rapidly inhibits factor Xa (1). Recently, the modification of these tri-peptide chloromethylketones with reporting groups, such as fluorescent probes (6-8), radioactive labels (9) or thioreactive-labels (10), has provided a unique approach to the study of various serine proteases. These probes are useful because they allow a means of reporting molecular changes in an enzyme, and not its zymogen, while also inhibiting the enzymatic activity. Applications: The fluorescein labeled compounds are useful in both Western blot and fluorescent imaging applications. |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | IF WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C5026 |
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| Order / More Info | Chloromethylketone-EGR, (EGRCK) FITC from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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