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| Product Name | Heregulin beta, EGF Domain (HRGb) |
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| Description | Purity >90% Purified by gel filtration chromatography (SDS-PAGE and Coomassie blue staining). . Heregulin is a glycoprotein, containing immunoglobulin-like and EGF-like domains, that is produced as a transmembrane proform and is expressed by a variety of cell types including neurons, astrocytes, fibroblasts and keratinocytes. At least 12 different heregulin isoforms, resulting from alternative splicing from a single gene, have been identified. The isoforms differ in the N-terminal, EGF-like, juxtamembrane domains and in the cytoplasmic tail. Thrombin cleaved GST fusion protein corresponding to the EGF domain of Heregulin-β3 (aa178-241). Biological Activity: Assessed by increased tyrosine phosphorylation of the c-erb B3/HER-3 receptor in Heregulin-beta treated MCF-7 cells. Receptor Activation Analysis: 5-25ng/ml of Heregulin activated the erbB-3/HER-3 receptor in MCF-7 cells. Heregulin stimulates tyrosine phosphorylation of the erbB-3/HER-3 receptor that was detected by monoclonal |
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| Size | 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H2030-50 |
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| Order / More Info | Heregulin beta, EGF Domain (HRGb) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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