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| Product Name | HER2/ErbB2 Blocking Peptide |
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| Description | Highly Purified. Peptide is used to block HER2/ErbB2 Rabbit mAb reactivity in immunohistochemistry protocols. The ErbB2 (HER2) proto-oncogene encodes a transmembrane receptor-like glycoprotein of 185kD with intrinsic tyrosine kinase activity (1). ErbB2 does not have any known ligand. However, the kinase activity of ErbB2 can be activated without ligand if it is overexpressed and by heteromeric association with other members of the ErbB family (2). Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers (3). Binding of the c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas. Direction of ErbB2 to the c-Cbl-regulated proteolytic pathway may have therapeutic potential. Tyr877 of ErbB2 is homologous to Tyr416 of pp60c-Src, located in the kinase domain. Phosphorylation of this sit |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | IHC |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H2031 |
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| Price | |
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| Order / More Info | HER2/ErbB2 Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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