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| Product Name | SKP1, Recombinant, Human, aa2-163, GST-Tag (S-phase Kinase-associated Protein 1) |
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| Description | Purity ~90% (SDS-PAGE). Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(F |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | S-phase Kinase-associated Protein 1, S-phase Kinase-associated Protein 1A, SKP1A, Cyclin A/CDK2-associated Protein p19, EMC19, MGC34403, Organ of Corti Protein 2, OCP 2, OCP2, OCP-2, OCP II, OCP-II Protein, p19A, p19skp1, RNA Polymerase II Elongation Factor-like Protein, SIII, Transcription Elongation Factor B, Transcription Elongation Factor B 1-like, Transcription Elongation Factor B SIII Polypeptide 1-like, TCEB1L |
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| Gene, Accession, CAS # | SwissProt: P63208 |
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| Catalog # | 375310 |
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| Order / More Info | SKP1, Recombinant, Human, aa2-163, GST-Tag (S-phase Kinase-associated Protein 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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