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| Product Name | SKP2, Recombinant, Human, aa1-424, His-SUMO-Tag (S-phase Kinase-associated Protein 2) |
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| Description | Purity ~90% (SDS-PAGE). Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. Source: Recombinant protein corresponding to aa1-424 from human SKP2, fused to His-SUMO-Tag at N-terminal expressed in E. coli. Molecular Weight: ~63.8kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cyclin-A/CDK2-associated protein p45F-box protein Skp2F-box/LRR-repeat protein 1p45skp2 |
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| Gene, Accession, CAS # | SwissProt: Q13309 |
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| Catalog # | 375311 |
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| Order / More Info | SKP2, Recombinant, Human, aa1-424, His-SUMO-Tag (S-phase Kinase-associated Protein 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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