| 产品详情 |
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| Product Name | Etoposide, 95.0-105.0% (HPLC) USP |
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| Description | Purity 95.0-105.0% (HPLC). Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a progressive inhibition of DNA replication. p53 activator. Blocks the cell cycle between the end of the S phase and the early G2 phase. Oncoprotein Mdm2 synthesis inhibitor. Apoptosis inducer through the cytochrome c/Apaf-1/caspase-9 pathway and the Fas-mediated death signaling pathway. Cell cycle checkpoint activator. Affects gene expression at different levels (chromatin remodeling, transcrip- tion and alternative splicing). Chemotherapeutic compound used in cancers. Used in conditioning regimen prior to a bone marrow or blood stem cell transplantation. Highly effective in mobilizing stem cells. Water (Karl Fischer): ≤ 6% Optical Rotation: [a]D20 = |
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| Size | 250mg, 1g, 5g |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4'-Desmethylepipodophyllotoxin; VP-16-213, NSC 141540 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 237745 |
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| Price | |
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| Order / More Info | Etoposide, 95.0-105.0% (HPLC) USP from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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